Polynucleotide treatments are intended to support skin quality rather than add volume or change facial shape. Here is an introduction to what they are, how they are administered and what to consider before deciding whether to proceed.
What are polynucleotides?
Polynucleotides are purified DNA fragments, commonly derived from fish sources. They are delivered through small injections and are intended to support the appearance of hydration, texture and elasticity in the treated area.
Products vary between manufacturers, and suitability and any relevant allergies are checked at consultation before any treatment is agreed. Results also vary from person to person and cannot be guaranteed.
How are they different from dermal fillers?
Dermal fillers add or restore volume and shape. Polynucleotides, by contrast, are intended to support the appearance and condition of the skin rather than to build volume or alter facial structure.
Which approach may be suitable depends on your specific concerns, your anatomy, your medical history and your preferences.
Where may they be used?
Depending on the product and your suitability, polynucleotides may be considered for areas such as the under-eye region, the face, the neck and the décolletage.
How many sessions might I need?
A course of sessions is commonly recommended. The exact timing and number of sessions is determined with you at consultation, based on your skin and your goals.
What might I experience afterwards?
Temporary raised areas, redness, tenderness, swelling or bruising may occur after treatment. It is wise to allow for visible signs in the days that follow and to follow any aftercare guidance you are given.
What does it cost?
- One area£275
- Two areas£300
- Three areas£375
- Pre-paid course of three — two areas£800
- Pre-paid course of three — three areas£999
Could it be suitable for me?
Consultation considers your skin concerns along with your medical history, any allergies, medicines you take, and whether you are pregnant or breastfeeding, as well as any other relevant contraindications. This ensures the treatment is only offered where it may reasonably be appropriate for you.
Last reviewed: August 2026